The human body contains hundreds of different types of cells. Most of these cells are located in the liver, kidneys and the brain and are responsible for maintaining the normal function of these organs.

Prof. Dr. Erdal Karaoz, the repository of the Stem Regenerative Cell Research and Production Center at LIV Istanbul Hospital, said, that: "In the last 10-15 years, stem cells, cells that provide the functioning of our organs and represent the key cell of the individual, have been divided into loborator and used in cellular treatments specific to each individual. Stem cells are used in the treatment of cartilage lesions in orthopedics, aesthetic and reparative surgery, burns and wounds with wound healing, in the case of inferior limbs in patients with diabetes, in cardiological lesions". 

The area of stem cell use can be divided into two main categories. They can be used in aesthetic and reparative surgery, orthopedics, dermatology and in the treatment of haematological disorders. However, there are conditions that can not be treated conventionally and that hope to be treated with stem cells, such as: nervous system disorders: Marital disorders, ALS neurogenic diseases, muscle disorders, organ failure, immune disorders , eye disorders such as loss of vision or lack of vision. In all these cases, stem cell treatment is expected.

Acne scars are a cosmetic problem. In treating these scars, dermatology has long used fillers. But, depending on the rate of degradation, this type of treatment requires repetition of the intervention. These products are less commonly used in the treatment of acne scars due to side effects. In the treatment of acne scars, fibroblast-cell injections are administered alone or in combination with laser and dermaroleri.

The biopsy performed in patients under treatment showed an increase in the volume of fibroblast cells and the epidermis without inflammation.

In addition, fibroblast cells with an active role in wound healing, scar formation, assuring the integrity of the skin's cellular structure are currently used in aesthetic surgery for rejuvenation purposes and in the treatment of dermatological disorders. Fibroblast cells are used to treat wounds, scars following varicella, burns, traumas, postoperative scars, and lip augmentation by removing their own cells.

Self-injected fibroblast cell injections are used to treat wrinkles, stains in the event of loss of skin elasticity as they age.

Fibroblast cells injected into the skin stimulate the synthesis of collagen and elastin itself in the area where it was applied, rebuilding the protein structure of the skin. Thus, the skin gets an anti-aging, youthful look.

The method of producing fibroblast cells consists of taking a 3 mm skin sample from a barely exposed area of ​​the sun's body, preferably behind the ear, the axillary or inguinal area by the punch biopsy method under sterile conditions. If the biopsy is done in a hairspace, it should be done so that it contains the hair follicle in the neck area. Besides the biopsy, blood will also be taken to produce endemic cells for each individual. From the biopsy material, the fibroblast cells are extracted by the enzymatic fragmentation method. After which the fibroblast cells are produced in sterile conditions. The production period of fibroblast cells varies between 4-6 weeks. At the end of the period there is a multiplication of no. cells sufficient to be transplanted. After performing the quality control and establishing the characteristics, the product is presented to the treating physician in vials specially prepared for administration. The injections are applied by the classical method of mesotherapy at the interval of 15-30 days, in total 3-4 sessions. The method does not require anesthesia.

Generally, these cells are administered to the patient from whom they were taken. But there are some cases, such as immune system disorders, when cells taken from the marrow or adipose tissue from another individual can be administered. This is possible due to the characteristic of these cells being recognized and accepted by the immune system of the transplant individual. Consequently, cells transplanted from another individual behave in the same way as the patient's own cells. This method is called allogeneic transplantation.

It is generally possible. After sufficient cell division, one part is administered to the patient. If the desired results are not recorded after the pathological examination, a second or three doses may also be given. Cells used for this purpose can be conserved in liquid nitrogen containers at -196 ° C. The tests have demonstrated that cells preserved under these conditions have retained their properties for 20 years.

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